Book Chapters

  1. Kaunas R. “Microfluidic Cell Culture” in in Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications, 7th Edition, Wiley-Blackwell, 2016.
  2. Ohashi T, Matsumoto T, Kaunas R, Deguchi S. “Cellular Biomechanics of the Vessel Wall” in Vascular Engineering, Springer, Berlin Heidelberg, 2015.
  3. Kaunas R. “Cell Behavior on Deformable Matrices” in Cell and Matrix Mechanics, Taylor & Francis, Boca Raton, FL, 2014. Co-editors Kaunas R and Zemel A.
  4. Tondon A, Haase C, Kaunas R. “Mechanical Stretch Assays in Cell Culture Systems” in CRC Handbook of Imaging in Biological Mechanics, Taylor & Francis, Boca Raton, FL, 2013.
  5. Kaunas R. “Modeling Cellular Adaptation to Mechanical Stress” in Bioengineering in Cell and Tissue Research, Springer-Verlag, Berlin Heidelberg, 2008

Peer-Reviewed Articles

2020

  • McNeill EP, Zeitouni S, Pan S, Clough BH, Krause U, Dobson LK, Kung C, Tahan D, Zhao Q , Saunders WB, Liu F, Kaunas R, Gregory CA. “A Pluripotent Stem Cell-Derived Matrix with Powerful Osteoregenerative Capabilities Shares the Basic Composition of Bone-Marrow Stromal Cell-Derived Matrices but is Superior in Efficacy" Nat Comm (in press).
  • Sears C, Mondragon E, Richards ZI, Sears N, Chimene D, McNeill EP, Gregory CA, Gaharwar AK, Kaunas R. “Conditioning of 3D Printed Nanoengineered Ionic–Covalent Entanglement Scaffolds with iP‐hMSCs Derived Matrix” Adv Health Mat. (in press)
  • Chimene D, Kaunas R, Gaharwar AK “Hydrogel Bioink Reinforcement for Additive Manufacturing: A Focused Review of Emerging Strategies” Adv Materials 2020; 32(1):1902026.
  • Kaunas R. “Good advice for endothelial cells: Get in line, relax tension, and go with the flow” APL Bioeng. 2020; 4(1):010905.

2019

  • Mota SM, Rogers RE, Haskell AW, McNeill EP, Giger ML, Kaunas R, Gregory CA, Maitland KC. “Morphological cell image analysis for real-time monitoring of stem cell culture” Proceedings Vol. 10883, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXVI; 108831I (2019) https://doi.org/10.1117/12.2507469
  • Cardoso GBC, *Tondon A, Maia LRB, Cunha MR, Zavaglia CAC, Kaunas R. “In vivo approach of calcium deficient hydroxyapatite filler as bone induction factor.” Mater Sci Eng C Mater Biol Appl. 2019 99:999-1006.

2018

  • McNeill EP, *Reese RW, *Tondon A, Clough BH, Pan S, Froese J, Palmer D, Krause U, Loeb DM, Kaunas R, Gregory CA. “Three-dimensional in vitro modeling of malignant bone disease recapitulates experimentally accessible mechanisms of osteoinhibition.” Cell Death Dis. 2018 9(12):1161.
  • Carrow JK, Cross LM, *Reese RW, Jaiswal MK, Gregory CA, Kaunas R, Singh I, Gaharwar AK. “Widespread changes in transcriptome profile of human mesenchymal stem cells induced by two-dimensional nanosilicates.” Proc Natl Acad Sci U S A. 2018 115(17):E3905-E3913.
  • Chimene D, Peak C, Gentry J, Carrow J, Cross L,*Mondragon E, Cardoso GB, Kaunas R, Gaharwar AK. "Nanoengineered Ionic-Covalent Entanglement (NICE) Bioinks for 3D Bioprinting." ACS Appl Mat Interfaces 2018 10(12):9957-9968.
  • Duran CL, Kaunas R, Bayless KJ. “S1P Synergizes with Wall Shear Stress and Other Angiogenic Factors to Induce Endothelial Cell Sprouting Responses.” Methods Mol Biol. 2018 1697:99-115.

2017

  • Mattison SP, *Mondragon E, Kaunas R, Applegate BE. “Hybrid nonlinear photoacoustic and reflectance confocal microscopy for label-free subcellular imaging with a single light source.” Opt Lett. 2017 42(19):4028-4031.

2016

  • Chimene D, Lennox KK, Kaunas R, Gaharwar AK. “Advanced Bioinks for 3D Printing: A Materials Science Perspective.” Ann Biomed Eng. 2016 44(6):2090-102.
  • Thakur T, Xavier JR, Cross L, Jaiswal MK, Mondragon E, Kaunas R, Gaharwar AK “Photocrosslinkable and elastomeric hydrogels for bone regeneration”, J Biomed Mater Res A. 2016, 104(4):879-88.
  • Sears C, Kaunas R. “The many ways adherent cells respond to applied stretch”, J Biomech. 2016, 49(8):1347-54..
  • Cardoso GB, Maniglio D, Volpato FZ, Tondon A, Migliaresi C, Kaunas R, Zavaglia CA. Oleic acid surfactant in polycaprolactone/hydroxyapatite-composites for bone tissue engineering. J Biomed Mater Res B Appl Biomater. 2016, 104(6):1076-82.

2015

  • Xavier JR, Thakur T, Desai P, Jaiswal MK, Sears N, Cosgriff-Hernandez E, Kaunas R, Gaharwar AK. “Bioactive nanosilicate-loaded hydrogels for bone tissue engineering: A growth-factor-free approach”, ACS Nano 2015, 9(3):3109-18..
  • Kang H, Duran CL, Abbey CA, Kaunas R, Bayless KJ “Fluid shear stress promotes proprotein convertase-dependent activation of MT1-MMP”, Biochem Biophys Res Commun. 2015, 460(3):596-602.
  • Jafarnejad, M., Cromer, W. E., Kaunas, R., Zhang, S. L., Zawieja, D. C., Moore, J. E. “Measurement of shear stress-mediated intracellular calcium dynamics in human dermal lymphatic endothelial cells”, Am J Physiol Heart Circ Physiol 2015, 1;308(7):H697-706.

before 2015

  • Tondon A and Kaunas R. “The direction of stretch-induced cell and stress fiber orientation depends on collagen matrix stress”, PLoS ONE 2014; 9(2):e89592.
  • Brown G, Butler PJ, Chang DW, Chien S, Clegg RM, Dewey CF, Dong C, Guo XE, Helmke BP, Hess H, Jacobs CR, Kaunas RR, Kumar S, Lu HH, Mathur AB, Mow VC, Schmid-Schönbein GW, Skoracki R, Wang N, Wang Y, Zhu C. “Cellular and molecular bioengineering: a tipping point”, Cell Mol Bioeng 2012; 5(3):239-253.
  • Hong, S., *Hsu, H.-J., Kaunas, R. and Kameoka, J. “Collagen microsphere production on a chip”, Lab Chip 2012; 12(18):3277-80.
  • Tondon, A., *Hsu, H.-J. and R. Kaunas, “Dependence of cyclic stretch-induced stress fiber reorientation on stretch waveform”, J Biomech 2012; 45(5):728-35.
  • Kang, H., Kwak, H.-I., Kaunas, R. and K. J. Bayless, “Fluid shear stress and sphingosine 1-phosphate activate calpain to promote membrane type 1 matrix metalloproteinase (MT1-MMP) membrane translocation and endothelial invasion into three-dimensional collagen matrices”, J Biol Chem 2011; 286(49):42017-26.
  • Kaunas, R., Kang, H. and K. J. Bayless, “Synergistic regulation of angiogenic sprouting by biochemical factors and wall shear stress”, Cell Mol Bioeng 2011; 4(4): 547-559.
  • Matsui, T.S., Kaunas, R., Kanzaki, M., Sato, M. and S. Deguchi, “Non-muscle myosin II induces disassembly of actin stress fibres independently of myosin light chain dephosphorylation”, Interface Focus 2011; 1:754-66.

…………………….tenured and promoted to the rank of associate professor…………………………….

  • Kaunas, R. and S. Deguchi, “Multiple roles for myosin II in tensional homeostasis under mechanical loading”, Cell Mol Bioeng 2011; 4(2):182–91.
  • Kaunas, R., Hsu, H-J., and S. Deguchi, Sarcomeric model of stretch-induced stress fiber reorganization, Cell Health and Cytoskeleton 2011; 3:13–22.
  • Lee, C-F., Haase, C., Deguchi, S. and R. Kaunas, “Cyclic stretch-induced stress fiber dynamics - dependence on strain rate, Rho-kinase and MLCK,” Biochem Biophys Res Commun. 2010; 401(3):344-9.
  • Hsu, H-J., Lee, C-F. Locke, A., Vanderzyl, S.Q. and R. Kaunas, “Stretch-induced stress fiber remodeling and the activations of JNK and ERK depend on mechanical strain rate, but not FAK”, PLoS ONE 2010; 5:e12470.
  • Matsui, T.S., Ito, K., Kaunas, R., Sato, M., and S. Deguchi,, “Actin stress fibers are at a tipping point between conventional shortening and rapid disassembly at physiological levels of MgATP,” Biochem Biophys Res Commun. 2010; 395:301-6.
  • Kaunas, R., Z. Huang, Z., and J. Hahn, A kinematic model coupling stress fiber dynamics with JNK activation in response to matrix stretching. J Theor Biol 2010; 264(2):593-603.
  • Hsu, H-J., Lee, C-F. and Kaunas, R., “A dynamic stochastic model of frequency-dependent stress fiber alignment induced by cyclic stretch” PLoS ONE 2009; 4:e4853.
  • Kaunas, R. and Hsu, H-J., “A kinematic model of stretch-induced stress fiber turnover and reorientation,” J Theo Biol. 2009; 257:20-30.
  • Kang, H., Bayless, K. J., and Kaunas, R., “Effects of fluid shear stress on endothelial cell invasion into three-dimensional matrices,” Am J Physiol Heart Circ Physiol 2008; 295:H2087-97.
  • Haga, J. H., Kaunas, R., Radeff-Huang, J., Weems, J. M., Estrada, K. D., Chien, S., Heller-Brown, J., and T. M. Seasholtz, “Pulsatile equibiaxial stretch increases NO production and decreases thrombin-induced RhoA and NF-kB activation in vascular smooth muscle cells,” Biochem Biophys Res Commun 2008; 372:216-20.
  • Wu, C. C., Li, Y. S., Haga, J. H., Kaunas, R., Chiu, J. J., Su, F. C., Usami, S., and S. Chien, “Directional shear flow and Rho activation prevent the endothelial cell apoptosis induced by micropatterned anisotropic geometry”, Proc Natl Acad Sci U S A, Vol. 104, No. 4 pp. 1254-9, 2007.
  • Kaunas, R., Usami, S., and Chien, S., Regulation of stretch-induced JNK activation by stress fiber orientation,” Cell Signal 2006; 18:1924-31.
  • Kaunas, R., Nguyen, P., Usami, S. and Chien S., "Cooperative effects of Rho and mechanical stretch on stress fiber organization," Proc Natl Acad Sci USA 2005; 102:15895-900.
  • Miao, H., Hu, Y. L., Shiu, Y. T., Yuan, S., Zhao, Y., Kaunas, R., Wang, Y., Jin, G., Usami, S., and Chien, S., “Effects of flow patterns on the localization and expression of VE-cadherin at vascular endothelial cell junctions: in vivo and in vitro investigations,” J Vasc Res 2005; 42:77-89.

 

Published before joining TAMU

  • Katsumi, A., Milanini, J., Kiosses, W., del Pozo, M. A., Kaunas, R., Chien, S., Hahn, K. and M. A. Schwartz. “Effects of cell tension on the small GTPase Rac”, J Cell Biol 2002;158(1):153-64.
  2. Katsumi, A., Milanini, J., Kiosses, W., del Pozo, M. A., Kaunas, R., Chien, S., Hahn, K. and M. A. Schwartz. Effects of cell tension on the small GTPase Rac, J Cell Biol, 2002;158(1):153-64
  3. Miao, H., Shiu, Y.-T., Hu, Y.-L., Yuan, S., Zhao, Y., Kaunas, R., Wang, Y., Jin, G., Usami, S. and S. Chien, Effects of flow patterns on the localization and expression of vascular endothelial cell junction proteins: In vivo and in vitro investigations, J Vasc Res, 2005;42(1):77-89.
  4. Kaunas, R., Nguyen, P., Usami, S. and S. Chien, Cooperative effects of Rho and mechanical stretch on stress fiber organization, PNAS 102(44):15895-15900, 2005.
  5. Kaunas, R., Usami, S. and S. Chien, Regulation of stretch-induced JNK activation by stress fiber orientation, Cell Signal, 2006; 18(11):1924-31.
  6. Wu, C. C., Li, Y. S., Haga, J. H., Kaunas, R., Chiu, J. J., Su, F. C., Usami, S., and S. Chien, Directional shear flow and Rho activation prevent the endothelial cell apoptosis induced by micropatterned anisotropic geometry, PNAS, 2007; 104(4):1254-9.
  7. Haga, J. H., Kaunas, R., Radeff-Huang, J., Weems, J. M., Estrada, K. D., Chien, S., Brown, J. H., and T. M. Seasholtz, Pulsatile equibiaxial stretch inhibits thrombin-induced RhoA and NF-kappaB activation. Biochem Biophys Res Commun. 2008; 372(1):216-20.
  8. Kang, H., Bayless, K. J., and R. Kaunas, Fluid shear stress modulates endothelial cell invasion into threedimensional collagen matrices, Am J Physiol, 2008; 295(5):H2087-97.
  9. Kaunas, R., and H. J. Hsu, A kinematic model of stretch-induced stress fiber turnover and reorientation. J Theo Biol 2009; 257(2):320-30.
  10. Hsu, H. J., Lee, C. F., and R. Kaunas, A dynamic stochastic model of frequency-dependent stress fiber alignment induced by cyclic stretch. PLoS ONE 2009; 4(3):e4853.
  11. Matsui, T.S., Ito, K., Kaunas, R., Sato, M., and S. Deguchi, Actin stress fibers are at a tipping point between conventional shortening and rapid disassembly at physiological levels of MgATP. Biochem Biophys Res Commun. 2010; 395(3):301-6.
  12. Kaunas, R., Z. Huang, Z., and J. Hahn, A kinematic model coupling stress fiber dynamics with JNK activation in response to matrix stretching. J Theor Biol. 2010; 264(2):593-603.
  13. Hsu, H-J., Locke, A., Lee, C-F., Vanderzyl, S. Q., and R. Kaunas, Involvement of cytoskeletal tension, but not FAK, in cyclic stretch-induced phosphorylation of JNK, p38 and ERK, PLoS ONE 2010; 5(8):e12470.
  14. Lee, C-F., Haase, C., Deguchi, S. and R. Kaunas, Cyclic Stretch-Induced Stress Fiber Dynamics - Dependence on Strain Rate, Rho-kinase and MLCK. Biochem Biophys Res Commun. 2010; 401(3):344-9.
  15. Kaunas, R., Hsu, H-J., and S. Deguchi, Sarcomeric model of stretch-induced stress fiber reorganization, Cell Health and Cytoskeleton 2011; 3:13-22.
  16. Kaunas, R. and S. Deguchi, Multiple roles for myosin II in tensional homeostasis under mechanical loading, Cell Mol Bioeng 2011; 4(2):182-91.
  17. Matsui, T.S., Kaunas, R., Kanzaki, M., Sato, M. and S. Deguchi, Non-muscle myosin II induces disassembly of actin stress fibres independently of myosin light chain dephosphorylation, Interface Focus 2011; 1:754-66.
  18. Kaunas, R., Kang, H. and K. J. Bayless, Synergistic regulation of angiogenic sprouting by biochemical factors and wall shear stress, Cell Mol Bioeng. 2011; 4(4):547-59.
  19. Kang, H., Kwak, H.-I., Kaunas, R. and K. J. Bayless, Fluid shear stress and sphingosine 1-phosphate activate calpain to promote membrane type 1 matrix metalloproteinase (MT1-MMP) membrane translocation and endothelial invasion into three-dimensional collagen matrices, J Biol Chem. 2011; 286(49):42017-26.
  20. Tondon, A., Hsu, H.-J. and R. Kaunas, Dependence of cyclic stretch-induced stress fiber reorientation on stretch waveform, J Biomech. 2012; 45(5):728-35.
  21. Hong, S., Hsu, H.-J., Kaunas, R. and Kameoka, J. Collagen microsphere production on a chip, Lab Chip 2012; 12(18):3277-80.
  22. Brown G, Butler PJ, Chang DW, Chien S, Clegg RM, Dewey CF, Dong C, Guo XE, Helmke BP, Hess H, Jacobs CR, Kaunas RR, Kumar S, Lu HH, Mathur AB, Mow VC, Schmid-Schönbein GW, Skoracki R, Wang N, Wang Y, Zhu C. “Cellular and Molecular Bioengineering: A Tipping Point”, Cell Mol Bioeng 2012; 5(3):239-253.
  23. Tondon A and Kaunas R. The direction of stretch-induced cell and stress fiber orientation depends on collagen matrix stress, PLoS ONE 2014; 9(2):e89592.