Book Chapters

  1. Kaunas, R. Modeling cellular adaptation to mechanical stress. In Bioengineering in Cell and Tissue Research, G.M. Artmann and S. Chien eds., Springer, 2008.
  2. Kaunas, R.  Dynamic Stress Fiber Reorganization on Stretched Matrices. In Cell and Matrix Mechanics, R. Kaunas and A. Zemel, CRC Press, 2014.
  3. Tondon, A., Haase, C. and Kaunas, R. Mechanical Stretch Assays in Cell Culture Systems. In  Handbook of Imaging in Biological Mechanics, G. Genin and C. Neu, CRC Press, 2014.


  1. Katsumi, A., Milanini, J., Kiosses, W., del Pozo, M. A., Kaunas, R., Chien, S., Hahn, K. and M. A. Schwartz. Effects of cell tension on the small GTPase Rac, J Cell Biol, 2002;158(1):153-64
  2. Miao, H., Shiu, Y.-T., Hu, Y.-L., Yuan, S., Zhao, Y., Kaunas, R., Wang, Y., Jin, G., Usami, S. and S. Chien, Effects of flow patterns on the localization and expression of vascular endothelial cell junction proteins: In vivo and in vitro investigations, J Vasc Res, 2005;42(1):77-89.
  3. Kaunas, R., Nguyen, P., Usami, S. and S. Chien, Cooperative effects of Rho and mechanical stretch on stress fiber organization, PNAS 102(44):15895-15900, 2005.
  4. Kaunas, R., Usami, S. and S. Chien, Regulation of stretch-induced JNK activation by stress fiber orientation, Cell Signal, 2006; 18(11):1924-31.
  5. Wu, C. C., Li, Y. S., Haga, J. H., Kaunas, R., Chiu, J. J., Su, F. C., Usami, S., and S. Chien, Directional shear flow and Rho activation prevent the endothelial cell apoptosis induced by micropatterned anisotropic geometry, PNAS, 2007; 104(4):1254-9.
  6. Haga, J. H., Kaunas, R., Radeff-Huang, J., Weems, J. M., Estrada, K. D., Chien, S., Brown, J. H., and T. M. Seasholtz, Pulsatile equibiaxial stretch inhibits thrombin-induced RhoA and NF-kappaB activation. Biochem Biophys Res Commun. 2008; 372(1):216-20.
  7. Kang, H., Bayless, K. J., and R. Kaunas, Fluid shear stress modulates endothelial cell invasion into threedimensional collagen matrices, Am J Physiol, 2008; 295(5):H2087-97.
  8. Kaunas, R., and H. J. Hsu, A kinematic model of stretch-induced stress fiber turnover and reorientation. J Theo Biol 2009; 257(2):320-30.
  9. Hsu, H. J., Lee, C. F., and R. Kaunas, A dynamic stochastic model of frequency-dependent stress fiber alignment induced by cyclic stretch. PLoS ONE 2009; 4(3):e4853.
  10. Matsui, T.S., Ito, K., Kaunas, R., Sato, M., and S. Deguchi, Actin stress fibers are at a tipping point between conventional shortening and rapid disassembly at physiological levels of MgATP. Biochem Biophys Res Commun. 2010; 395(3):301-6.
  11. Kaunas, R., Z. Huang, Z., and J. Hahn, A kinematic model coupling stress fiber dynamics with JNK activation in response to matrix stretching. J Theor Biol. 2010; 264(2):593-603.
  12. Hsu, H-J., Locke, A., Lee, C-F., Vanderzyl, S. Q., and R. Kaunas, Involvement of cytoskeletal tension, but not FAK, in cyclic stretch-induced phosphorylation of JNK, p38 and ERK, PLoS ONE 2010; 5(8):e12470.
  13. Lee, C-F., Haase, C., Deguchi, S. and R. Kaunas, Cyclic Stretch-Induced Stress Fiber Dynamics - Dependence on Strain Rate, Rho-kinase and MLCK. Biochem Biophys Res Commun. 2010; 401(3):344-9.
  14. Kaunas, R., Hsu, H-J., and S. Deguchi, Sarcomeric model of stretch-induced stress fiber reorganization, Cell Health and Cytoskeleton 2011; 3:13-22.
  15. Kaunas, R. and S. Deguchi, Multiple roles for myosin II in tensional homeostasis under mechanical loading, Cell Mol Bioeng 2011; 4(2):182-91.
  16. Matsui, T.S., Kaunas, R., Kanzaki, M., Sato, M. and S. Deguchi, Non-muscle myosin II induces disassembly of actin stress fibres independently of myosin light chain dephosphorylation, Interface Focus 2011; 1:754-66.
  17. Kaunas, R., Kang, H. and K. J. Bayless, Synergistic regulation of angiogenic sprouting by biochemical factors and wall shear stress, Cell Mol Bioeng. 2011; 4(4):547-59.
  18. Kang, H., Kwak, H.-I., Kaunas, R. and K. J. Bayless, Fluid shear stress and sphingosine 1-phosphate activate calpain to promote membrane type 1 matrix metalloproteinase (MT1-MMP) membrane translocation and endothelial invasion into three-dimensional collagen matrices, J Biol Chem. 2011; 286(49):42017-26.
  19. Tondon, A., Hsu, H.-J. and R. Kaunas, Dependence of cyclic stretch-induced stress fiber reorientation on stretch waveform, J Biomech. 2012; 45(5):728-35.
  20. Hong, S., Hsu, H.-J., Kaunas, R. and Kameoka, J. Collagen microsphere production on a chip, Lab Chip 2012; 12(18):3277-80.
  21. Brown G, Butler PJ, Chang DW, Chien S, Clegg RM, Dewey CF, Dong C, Guo XE, Helmke BP, Hess H, Jacobs CR, Kaunas RR, Kumar S, Lu HH, Mathur AB, Mow VC, Schmid-Schönbein GW, Skoracki R, Wang N, Wang Y, Zhu C. “Cellular and Molecular Bioengineering: A Tipping Point”, Cell Mol Bioeng 2012; 5(3):239-253.
  22. Tondon A and Kaunas R. The direction of stretch-induced cell and stress fiber orientation depends on collagen matrix stress, PLoS ONE 2014; 9(2):e89592.